Publications in Doreen Dobritzsch Group

  • Lenherr, Nina; Christodoulou, John; Duley, John; Dobritzsch, Doreen et al.

    Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

    Part of Molecular Genetics and Metabolism Reports, 2021.

    Open access
  • FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

    Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

    Part of RSC Advances, p. 7527-7537, 2021.

    Open access
  • Puusepp, Sanna; Reinson, Karit; Pajusalu, Sander; van Kuilenburg, Andre B. P. et al.

    Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

    Part of Molecular Based Mathematical Biology, 2020.

    Open access
  • Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

    Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

    Part of ACS Omega, p. 3979-3995, 2020.

    Open access
  • van Kuilenburg, Andre B. P.; Tarailo-Graovac, Maja; Richmond, Phillip A.; Drogemoller, Britt I. et al.

    Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

    Part of New England Journal of Medicine, p. 1433-1441, 2019.

  • Ge, Changrong; Xu, Bingze; Liang, Bibo; Lönnblom, Erik et al.

    Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies

    Part of Arthritis & Rheumatology, p. 210-221, 2019.

  • Maurer, Dirk; Lohkamp, Bernhard; Krumpel, Michael; Widersten, Mikael et al.

    Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism

    Part of Biochemical Journal, p. 2395-2416, 2018.

  • Hamnevik, Emil; Maurer, Dirk; Enugala, Thilak Reddy; Chu, Thao et al.

    Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-Diol and Its Corresponding Acyloin

    Part of Biochemistry, p. 1059-1062, 2018.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreen; Kamerlin, Shina C Lynn et al.

    Epoxide Hydrolysis as a Model System for Understanding Flux Through a Branched Reaction Scheme

    Part of IUCrJ, p. 269-282, 2018.

    Open access
  • van Kuilenburg, André; Tarailo-Graovac, Maja; Meijer, Judith; Drogemoller, Britt et al.

    Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G > A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

    Part of Human Mutation, p. 947-953, 2018.

  • Hampel, Sabrina; Steitz, Jan-Patrick; Baierl, Anna; Lehwald, Patrizia et al.

    Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens

    Part of ChemBioChem (Print), p. 2283-2292, 2018.

  • Ge, Changrong P; Tong, Dongmei R; Liang, Bibo T; Lönnblom, Erik S et al.

    Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

    Part of JCI INSIGHT, 2017.

  • Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

    Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity

    Part of Molecular Genetics and Metabolism, p. 216-222, 2017.

  • Porrmann, Joseph; Betcheva-Krajcir, Elitza; Di Donato, Nataliya; Kahlert, Anne-Karin et al.

    Novel PRPS1 gain-of-function mutation in a patient with congenital hyperuricemia and facial anomalies

    Part of American Journal of Medical Genetics. Part A, p. 2736-2742, 2017.

  • Hamnevik, Emil; Enugala, Thilak Reddy; Maurer, Dirk; Ntuku, Siphosethu et al.

    Relaxation of Nonproductive Binding and Increased Rate of Coenzyme Release in an Alcohol Dehydrogenase Increases Turnover With a Non-Preferred Alcohol Enantiomer

    Part of The FEBS Journal, p. 3895-3914, 2017.

    Open access
  • van Kuilenburg, André B P; Meijer, Judith; Maurer, Dirk; Dobritzsch, Doreen et al.

    Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing

    Part of Biochimica et Biophysica Acta, p. 721-730, 2017.

  • Nakajima, Yoko; Meijer, Judith; Zhang, Chunhua; Wang, Xu et al.

    Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene.

    Part of International Journal of Molecular Sciences, 2016.

    Open access
  • Bauer, Paul; Janfalk Carlsson, Åsa; Amrein, Beat A.; Dobritzsch, Doreen et al.

    Conformational Diversity and Enantioconvergence in Potato Epoxide Hydrolase 1

    Part of Organic and biomolecular chemistry, p. 5639-5651, 2016.

    Open access
  • Doak, Bradley C; Zheng, Jie; Dobritzsch, Doreen; Kihlberg, Jan

    How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

    Part of Journal of Medicinal Chemistry, p. 2312-2327, 2016.

  • Janfalk Carlsson, Åsa; Bauer, Paul; Dobritzsch, Doreeen; Nilsson, Mikael et al.

    Laboratory evolved enzymes provide snapshots of the development of enantioconvergence in enzyme-catalyzed epoxide hydrolysis

    Part of ChemBioChem (Print), p. 1693-1697, 2016.

    Open access
  • Kuilenburg, André B P van; Meijer, Judith; Tanck, Michael W T; Dobritzsch, Doreen et al.

    Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

    Part of Biochimica et Biophysica Acta, p. 754-762, 2016.

  • Lindgren, Cecilia; Andersson, Ida E.; Berg, Lotta; Dobritzsch, Doreen et al.

    Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes

    Part of Organic and biomolecular chemistry, p. 6203-6216, 2015.

    Open access
  • Haag, Sabrina; Tuncel, Jonatan; Thordardottir, Soley; Mason, Daniel E. et al.

    Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

    Part of Journal of Immunology, p. 2539-2550, 2015.

  • Nakajima, Yoko; Meijer, Judith; Dobritzsch, Doreen; Ito, Tetsuya et al.

    Clinical, biochemical and molecular analysis of 13 Japanese patients with beta-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

    Part of Journal of Inherited Metabolic Disease, p. 801-812, 2014.

    Open access
  • Raposo, Bruno; Dobritzsch, Doreen; Ge, Changrong; Ekman, Diana et al.

    Epitope-specific antibody response is controlled by immunoglobuline VH polymorphisms

    Part of Journal of Experimental Medicine, p. 405-411, 2014.

  • Dobritzsch, Doreen; Wang, Huaming; Schneider, Gunter; Yu, Shukun

    Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

    Part of Biochemical Journal, p. 441-452, 2014.

  • Claesson, Magnus; Siitonen, Vilja; Dobritzsch, Doreen; Metsä-Ketelä, Mikko et al.

    Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

    Part of The FEBS Journal, p. 3251-3263, 2012.

  • van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Krumpel, Michael et al.

    ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients

    Part of Biochimica et Biophysica Acta, p. 1096-108, 2012.

    Open access
  • Dobritzsch, Doreen; Lindh, Ingrid; Uysal, Hüseyin; Nandakumar, Kutty S et al.

    Crystal structure of an arthritogenic anticollagen immune complex

    Part of Arthritis and Rheumatism, p. 3740-3748, 2011.

  • van Kuilenburg, André B P; Dobritzsch, Doreen; Meijer, Judith; Meinsma, Rutger et al.

    Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients

    Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, p. 639-648, 2010.

  • Lohkamp, Bernhard; Voevodskaya, Nina; Lindqvist, Ylva; Dobritzsch, Doreen

    Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination

    Part of Biochimica et Biophysica Acta, p. 2198-2206, 2010.

  • van Kuilenburg, André B P; Meijer, Judith; Mul, Adri N P M; Meinsma, Rutger et al.

    Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

    Part of Human Genetics, p. 529-538, 2010.

  • Lohkamp, Bernhard; Dobritzsch, Doreen

    A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein

    Part of Acta Crystallographica Section D, p. 407-415, 2008.

  • Andersen, Birgit; Lundgren, Stina; Dobritzsch, Doreen; Piskur, Jure

    A recruited protease is involved in catabolism of pyrimidines

    Part of Journal of Molecular Biology, p. 243-250, 2008.

  • Schnackerz, Klaus D; Dobritzsch, Doreen

    Amidohydrolases of the reductive pyrimidine catabolic pathway: purification, characterization, structure, reaction mechanisms and enzyme deficiency

    Part of Biochimica et Biophysica Acta, p. 431-444, 2008.

  • Schnackerz, K D; Andersen, G; Dobritzsch, Doreen; Piskur, J

    Degradation of pyrimidines in Saccharomyces kluyveri: transamination of beta-alanine

    Part of Nucleosides, Nucleotides & Nucleic Acids, p. 794-799, 2008.

  • van Kuilenburg, A B P; Meijer, J; Dobritzsch, Doreen; Lohkamp, B et al.

    Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria

    Part of Nucleosides, Nucleotides & Nucleic Acids, p. 809-815, 2008.

  • Beck, Halfdan; Dobritzsch, Doreen; Piskur, Jure

    Saccharomyces kluyveri as a model organism to study pyrimidine degradation

    Part of FEMS yeast research (Print), p. 1209-1213, 2008.

  • Lundgren, Stina; Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure et al.

    The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly

    Part of Journal of Molecular Biology, p. 1544-1559, 2008.

  • Andersen, Gorm; Andersen, Birgit; Dobritzsch, Doreen; Schnackerz, Klaus D et al.

    A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast

    Part of The FEBS Journal, p. 1804-1017, 2007.

  • van Kuilenburg, André B P; Meijer, Judith; Dobritzsch, Doreen; Meinsma, Rutger et al.

    Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency

    Part of Molecular Genetics and Metabolism, p. 157-164, 2007.

  • Koskiniemi, Hanna; Metsä-Ketelä, Mikko; Dobritzsch, Doreen; Kallio, Pauli et al.

    Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis

    Part of Journal of Molecular Biology, p. 633-648, 2007.

  • Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    Crystal structures of yeast beta-alanine synthase complexes reveal the mode of substrate binding and large scale domain closure movements

    Part of Journal of Biological Chemistry, p. 36037-36047, 2007.

  • Lundgren, Stina; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster

    Part of Acta Crystallographica. Section F, p. 874-877, 2007.

  • Andersen, G; Merico, A; Björnberg, O; Andersen, B et al.

    Catabolism of pyrimidines in yeast: a tool to understand degradation of anticancer drugs

    Part of Nucleosides, Nucleotides & Nucleic Acids, p. 991-996, 2006.

  • Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum

    Part of Acta Crystallographica. Section F, p. 36-38, 2006.

  • Lohkamp, Bernhard; Andersen, Birgit; Piskur, Jure; Dobritzsch, Doreen

    The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity

    Part of Journal of Biological Chemistry, p. 13762-13776, 2006.

  • Dobritzsch, Doreen; Andersen, Birgit; Piskur, Jure

    Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri

    Part of Acta Crystallographica. Section F, p. 359-362, 2005.

  • Van Kuilenburg, André B P; Meinsma, Rutger; Beke, Eva; Bobba, Barbara et al.

    Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

    Part of Biological chemistry (Print), p. 319-324, 2005.

  • Schnackerz, Klaus D; Dobritzsch, Doreen; Lindqvist, Ylva; Cook, Paul F

    Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters

    Part of Biochimica et Biophysica Acta, p. 61-74, 2004.

  • Dobritzsch, Doreen; Gojković, Zoran; Andersen, Birgit; Piskur, Jure

    Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri

    Part of Acta Crystallographica Section D, p. 1267-1269, 2003.

  • Lundgren, Stina; Gojković, Zoran; Piskur, Jure; Dobritzsch, Doreen

    Yeast beta-alanine synthase shares a structural scaffold and origin with dizinc-dependent exopeptidases

    Part of Journal of Biological Chemistry, p. 51851-51862, 2003.

  • Dobritzsch, Doreen; Ricagno, Stefano; Schneider, Gunter; Schnackerz, Klaus D et al.

    Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil: Implications for mechanism of inhibition and electron transfer

    Part of Journal of Biological Chemistry, p. 13155-13166, 2002.

  • van Kuilenburg, André B P; Dobritzsch, Doreen; Meinsma, Rutger; Haasjes, Janet et al.

    Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

    Part of Biochemical Journal, p. 157-163, 2002.

  • Dobritzsch, Doreen; Schneider, G; Schnackerz, K D; Lindqvist, Y

    Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil

    Part of EMBO Journal, p. 650-660, 2001.

  • Dobritzsch, Doreen; Persson, K; Schneider, G; Lindqvist, Y

    Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase

    Part of Acta Crystallographica Section D, p. 153-155, 2001.

  • Lu, G; Dobritzsch, Doreen; Baumann, S; Schneider, G et al.

    The structural basis of substrate activation in yeast pyruvate decarboxylase: A crystallographic and kinetic study

    Part of European Journal of Biochemistry, p. 861-868, 2000.

  • Dobritzsch, Doreen; König, S; Schneider, G; Lu, G

    High resolution crystal structure of pyruvate decarboxylase from Zymomonas mobilis: Implications for substrate activation in pyruvate decarboxylases

    Part of Journal of Biological Chemistry, p. 20196-20204, 1998.

  • Lu, G; Dobritzsch, Doreen; König, S; Schneider, G

    Novel tetramer assembly of pyruvate decarboxylase from brewer's yeast observed in a new crystal form

    Part of FEBS Letters, p. 249-253, 1997.