Publications in Helena Danielson Group

  • FitzGerald, Edward A.; Butko, Margaret T.; Boronat, Pierre; Cederfelt, Daniela et al.

    Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

    Part of RSC Advances, p. 7527-7537, 2021.

    Open access
  • Encarnacao, Joao Crispim; Napolitano, Valeria; Opassi, Giulia; Danielson, U. Helena et al.

    A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells

    Part of FEBS Letters, p. 2406-2420, 2020.

    Open access
  • Opassi, Giulia; Nordström, Helena; Lundin, Arne; Napolitano, Valeria et al.

    Establishing Trypanosoma cruzi farnesyl pyrophosphatesynthase as a viable target for biosensor driven fragment-based lead discovery

    Part of Protein Science, p. 991-1003, 2020.

    Open access
  • Xu, Xingxing; Makaraviciute, Asta; Abdurakhmanov, Eldar; Werneling, Fredrik et al.

    Estimating Detection Limits of Potentiometric DNA sensors Using Surface Plasmon Resonance Analyses

    Part of ACS Sensors, p. 217-224, 2020.

  • Öhman Fuchs, Peder; Calitz, Carlemi; Pavlovic, Natasa; Binet, Francois et al.

    Fibrin fragment E potentiates TGF-beta-induced myofibroblast activation and recruitment

    Part of Cellular Signalling, 2020.

    Open access
  • Yang, Jie; Talibov, Vladimir O; Peintner, Stefan; Rhee, Claire et al.

    Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

    Part of ACS Omega, p. 3979-3995, 2020.

    Open access
  • Xu, Xingxing; Makaraviciute, Asta; Kumar, Shalen; Wen, Chenyu et al.

    Structural Changes of Mercaptohexanol Self-assembled Monolayers on Gold and their Influence on Impedimetric Aptamer Sensors

    Part of Analytical Chemistry, p. 14697-14704, 2019.

  • Fabini, Edoardo; Talibov, Vladimir O; Mihalic, Filip; Naldi, Marina et al.

    Unveiling the Biochemistry of the Epigenetic Regulator SMYD3

    Part of Biochemistry, p. 3634-3645, 2019.

  • Linkuviene, Vaida; Talibov, Vladimir O; Danielson, U. Helena; Matulis, Daumantas

    Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design

    Part of Journal of Medicinal Chemistry, p. 2292-2302, 2018.

  • Pandya, Nikhil J; Seeger, Christian; Babai, Norbert; Gonzalez-Lozano, Miguel A et al.

    Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

    Part of Cell reports, p. 1218-1230, 2018.

    Open access
  • Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

    Pan-NS3 protease inhibitors of hepatitis C virus based on an R3-elongated pyrazinone scaffold

    Part of European Journal of Medicinal Chemistry, p. 453-464, 2018.

  • Seeger, Christian; Talibov, Vladimir O; Danielson, U. Helena

    Biophysical analysis of the dynamics of calmodulin interactions with neurogranin and Ca2+/calmodulin-dependent kinase II

    Part of Journal of Molecular Recognition, p. 1-11, 2017.

    Open access
  • Abdurakhmanov, Eldar; Solbak, Sara Oie; Danielson, U. Helena

    Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase

    Part of Viruses, 2017.

    Open access
  • Solbak, Sara M.Ø.; Abdurakhmanov, Eldar; Vedeler, Anni; Danielson, U. Helena

    Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA - effects on NS5B catalysis and allosteric inhibition

    Part of Virology Journal, 2017.

    Open access
  • Saupe, Falk; Reichel, Matthias; Huijbers, Elisabeth J. M.; Femel, Julia et al.

    Development of a novel therapeutic vaccine carrier that sustains high antibody titers against several targets simultaneously

    Part of The FASEB Journal, p. 1204-1214, 2017.

  • Nosrati, Masoumeh; Solbak, Sara; Nordesjö, Olle; Nissbeck, Mikael et al.

    Insights from engineering the Affibody-Fc interaction with a computational-experimental method

    Part of Protein Engineering Design & Selection, p. 593-601, 2017.

  • Linkuviene, V.; Talibov, Vladimir O.; Danielson, U. Helena; Matulis, D.

    Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

    Part of European Biophysics Journal, p. S91-S91, 2017.

  • Linkuviene, V.; Talibov, Vladimir O; Danielson, U. Helena; Matulis, D.

    Intrinsic vs. observed thermodynamic and kinetic parameters of carbonic anhydrase-ligand interaction

    Part of European Biophysics Journal, p. S311-S311, 2017.

  • Fabini, Edoardo; Danielson, U. Helena

    Monitoring drug-serum protein interactions for early ADME prediction through Surface Plasmon Resonance technology

    Part of Journal of Pharmaceutical and Biomedical Analysis, p. 188-194, 2017.

  • Renaud, Jean-Paul; Chung, Chun-wa; Danielson, U. Helena; Egner, Ursula et al.

    Biophysics in drug discovery: impact, challenges and opportunities

    Part of Nature reviews. Drug discovery, p. 679-698, 2016.

  • Belfrage, Anna Karin; Abdurakhmanov, Eldar; Åkerblom, Eva; Brandt, Peter et al.

    Discovery of pyrazinone based compounds that potently inhibit the drug resistant enzyme variant R155K of the hepatitis C virus NS3 protease

    Part of Bioorganic & Medicinal Chemistry, p. 2603-2620, 2016.

  • Talibov, Vladimir O; Linkuvienė, Vaida; Matulis, Daumantas; Danielson, Helena U.

    Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII

    Part of Journal of Medicinal Chemistry, p. 2083-2093, 2016.

  • Raykova, Doroteya; Koos, Bjoern; Asplund, Anna; Gelleri, Marton et al.

    Let There Be Light!

    Part of Proteomes, 2016.

    Open access
  • Danielson, U Helena; Huang, H H; Seeger, Christian; Lindblad, Peter

    Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

    Part of BMC Research Notes, p. 459-, 2015.

  • Huang, Hsin-Ho; Seeger, Christian; Danielson, U. Helena; Lindblad, Peter

    Analysis of the leakage of gene repression by an artificial TetR-regulated promoter in cyanobacteria

    Part of BMC Research Notes, 2015.

    Open access
  • Anscombe, Elizabeth; Meschini, Elisa; Mora-Vidal, Regina; Martin, Mathew P. et al.

    Identification and Characterization of an Irreversible Inhibitor of CDK2

    Part of Chemistry and Biology, p. 1159-1164, 2015.

    Open access
  • Spurny, Radovan; Debaveye, Sarah; Farinha, Ana; Veys, Ken et al.

    Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the alpha 7 nicotinic acetylcholine receptor

    Part of Proceedings of the National Academy of Sciences of the United States of America, p. E2543-E2552, 2015.

  • Danielson, U. Helena

    Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function

    Part of Multifaceted Roles Of Crystallography In Modern Drug Discovery, p. 223-240, 2015.

  • Koos, Björn; Cane, Gaëlle; Grannas, Karin; Löf, Liza et al.

    Proximity-dependent initiation of hybridization chain reaction

    Part of Nature Communications, 2015.

    Open access
  • Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Muhammad Ikram; Svahn Gustafsson, Sofia et al.

    Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors

    Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 868-876, 2014.

  • Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica et al.

    Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket

    Part of Journal of Medicinal Chemistry, p. 1790-1801, 2014.

  • Martin, M.; Anscombe, E.; Meschini, E.; Staunton, D. et al.

    Identification and characterization of an irreversible inhibitor of CDK2

    Part of European Journal of Cancer, p. 106-106, 2014.

  • Svahn Gustafsson, Sofia; Ehrenberg, Angelica; Schmuck, Benjamin; Anwar, Mohammed Ikram et al.

    Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic variants

    Part of Journal of Medicinal Chemistry, p. 1802-1811, 2014.

  • Lampa, Anna; Bergman, Sara; Svahn Gustafsson, Sofia; Alogheli, Hiba et al.

    Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region

    Part of ACS Medicinal Chemistry Letters, p. 249-254, 2014.

  • Manfroni, Giuseppe; Cannalire, Rolando; Barreca, Maria Letizia; Kaushik-Basu, Neerja et al.

    The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

    Part of Journal of Medicinal Chemistry, p. 1952-1963, 2014.

  • Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Åkerblom, Eva et al.

    Vinylated linear P2 pyrimidinyloxyphenylglycine based inhibitors of the HCV NS3/4A protease and corresponding macrocycles

    Part of Bioorganic & Medicinal Chemistry, p. 6595-6615, 2014.

  • Christopeit, Tony; Øverbø, Kersti; Danielson, Helena; Nilsen, Inge W.

    Efficient Screening of Marine Extracts for Protease Inhibitors by Combining FRET Based Activity Assays and Surface Plasmon Resonance Spectroscopy Based Binding Assays

    Part of Marine Drugs, p. 4279-4293, 2013.

    Open access
  • Winquist, Johan; Geschwindner, Stefan; Xue, Yafeng; Gustavsson, Lars et al.

    Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

    Part of Biochemistry, p. 613-626, 2013.

  • Sussman, Fredy; Carmen Villaverde, M.; Dominguez, Jose L.; Danielson, Helena

    On the Active Site Protonation State in Aspartic Proteases: Implications for Drug Design

    Part of Current pharmaceutical design, p. 4257-4275, 2013.

  • Winquist, Johan; Abdurakhmanov, Eldar; Baraznenok, Vera; Henderson, Ian et al.

    Resolution of the Interaction Mechanisms and Characteristics of Non-nucleoside Inhibitors of Hepatitis C Virus Polymerase - Laying the Foundation for Discovery of Allosteric HCV Drugs

    Part of Antiviral Research, p. 356-368, 2013.

  • Kesters, D.; Thompson, A. J.; Brams, M.; Van Elk, R. et al.

    Structural basis of ligand recognition in 5-HT3 receptors

    Part of EMBO Reports, p. 49-56, 2013.

  • Barreca, Maria Letizia; Manfroni, Giuseppe; Leyssen, Pieter; Winquist, Johan et al.

    Structure-Based Discovery of Pyrazolobenzothiazine Derivatives As Inhibitors of Hepatitis C Virus Replication

    Part of Journal of Medicinal Chemistry, p. 2270-2282, 2013.

  • Gossas, Thomas; Nordström, Helena; Xu, Ming-Hua; Sun, Zhi-Hua et al.

    The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors: characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

    Part of MedChemComm, p. 432-442, 2013.

  • Gorny, Xenia; Mikhaylova, Marina; Seeger, Christian; Reddy, Pasham Parameshwar et al.

    AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

    Part of Journal of Neurochemistry, p. 714-726, 2012.

  • Gossas, Thomas; Vrang, Lotta; Henderson, Ian; Sedig, Susanne et al.

    Aliskiren displays long-lasting interactions with human renin

    Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 219-224, 2012.

  • Seeger, Christian; Christopeit, Tony; Fuchs, K.; Grote, K. et al.

    Corrigendum to "Histaminergic pharmacology of homo-oligomeric β3 γ-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology" (Biochemical Pharmacology (2012) 84 (341-351))

    Part of Biochemical Pharmacology, p. 1541-, 2012.

  • Dominguez, Jose L.; Gossas, Thomas; Carmen Villaverde, M.; Danielson, U. Helena et al.

    Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: Implications for the charge state of the protein ionogenic groups

    Part of Bioorganic & Medicinal Chemistry, p. 4838-4847, 2012.

  • Seeger, Christian; Christopeit, Tony; Fuchs, Karoline; Grote, Katharina et al.

    Histaminergic pharmacology of homo-oligomeric beta 3 gamma-aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

    Part of Biochemical Pharmacology, p. 341-351, 2012.

  • Seeger, Christian; Gorny, Xenia; Reddy, Pasham Parameshwar; Seidenbecher, Constanze et al.

    Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function

    Part of Journal of Molecular Recognition, p. 495-503, 2012.

  • Christopeit, Tony; Stenberg, Gun; Gossas, Thomas; Nyström, Susanne et al.

    A surface plasmon resonance-based biosensor with full-length BACE1 in a reconstituted membrane

    Part of Analytical Biochemistry, p. 14-22, 2011.

  • Brandt, Peter; Geitmann, Matthis; Danielson, U Helena

    Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

    Part of Journal of Medicinal Chemistry, 2011.

  • Elinder, Malin; Geitmann, Matthis; Gossas, Thomas; Källblad, Per et al.

    Experimental Validation of a Fragment Library for Lead Discovery Using SPR Biosensor Technology

    Part of Journal of Biomolecular Screening, p. 15-25, 2011.

  • Geitmann, Matthis; Elinder, Malin; Seeger, Christian; Brandt, Peter et al.

    Identification of a Novel Scaffold for Allosteric Inhibition of Wild Type and Drug Resistant HIV-1 Reverse Transcriptase by Fragment Library Screening

    Part of Journal of Medicinal Chemistry, p. 699-708, 2011.

  • Geitmann, Matthis; Dahl, Göran; Danielson, U. Helena

    Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

    Part of Journal of Molecular Recognition, p. 60-70, 2011.

  • Lampa, Anna; Ehrenberg, Angelica E.; Vema, Aparna; Åkerblom, Eva et al.

    P2-P1 ' macrocyclization of P2 phenylglycine based HCV NS3 protease inhibitors using ring-closing metathesis

    Part of Bioorganic & Medicinal Chemistry, p. 4917-4927, 2011.

  • Tegler, Lotta T.; Nonglaton, Guillaume; Büttner, Frank; Caldwell, Karin et al.

    Powerful protein binders from designed polypeptides and small organic molecules: a general concept for protein recognition

    Part of Angewandte Chemie International Edition, p. 1823-1827, 2011.

  • Gustafsson, Sofia S.; Vrang, Lotta; Terelius, Ylva; Danielson, Helena

    Quantification of interactions between drug leads and serum proteins by use of "binding efficiency"

    Part of Analytical Biochemistry, p. 163-175, 2011.

  • Belfrage, Anna-Karin; Gising, Johan; Örtqvist, Pernilla; Alogheli, Hiba et al.

    Synthesis and SAR Around the R6 Position of 2(1H)-Pyrazinone Based HCV NS3 Protease Inhibitors

    Part of Biopolymers, p. 457-457, 2011.

  • Lundquist, Anna; Hansen, Søren B; Nordström, Helena; Danielson, U Helena et al.

    Biotinylated lipid bilayer disks as model membranes for biosensor analyses

    Part of Analytical Biochemistry, p. 153-159, 2010.

  • Retra, Kim; Geitmann, Matthis; Kool, Jeroen; Smit, August B et al.

    Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands

    Part of Analytical Biochemistry, p. 58-64, 2010.

  • Örtqvist, Pernilla; Gising, Johan; Ehrenberg, Angelica; Vema, Aparna et al.

    Discovery of Achiral Inhibitors of the Hepatitis C Virus NS3 Protease based on 2(1H)-pyrazinones

    Part of Bioorganic & Medicinal Chemistry, p. 6512-6525, 2010.

  • Domínguez, José L; Christopeit, Tony; Villaverde, M Carmen; Gossas, Thomas et al.

    Effect of the Protonation State of the Titratable Residues on the Inhibitor Affinity to BACE-1

    Part of Biochemistry, p. 7255-7263, 2010.

  • Gising, Johan; Belfrage, Anna Karin; Örtqvist, Pernilla; Larhed, Mats et al.

    Hepatitis C protease inhibitors based on 2(1H)-pyrazinones

    Part of Abstracts of Papers of the American Chemical Society, p. 116-MEDI-, 2010.

  • Belfrage, Anna-Karin; Gising, Johan; Örtqvist, Pernilla; Danielson, U Helena et al.

    Hepatitis C Virus NS3 Protease Inhibitors based on 2(1H)-Pyrazinones

    Part of Journal of Peptide Science, p. 95-95, 2010.

  • Lampa, Anna; Ehrenberg, Angelica E.; Gustafsson, Sofia S.; Vema, Aparna et al.

    Improved P2 phenylglycine-based hepatitis C virus NS3 protease inhibitors with alkenylic prime-side substituents

    Part of Bioorganic & Medicinal Chemistry, p. 5413-5424, 2010.

  • Elinder, Malin; Selhorst, Philippe; Vanham, Guido; Öberg, Bo et al.

    Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism: Importance of slow dissociation and relaxation rates for antiviral efficacy

    Part of Biochemical Pharmacology, p. 1133-1140, 2010.

  • Geitmann, Matthis; Retra, Kim; de Kloe, Gerdien E; Homan, Evert et al.

    Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

    Part of Biochemistry, p. 8143-8154, 2010.

  • Örtqvist, Pernilla; Vema, Aparna; Ehrenberg, Angelica E; Dahl, Göran et al.

    Structure-activity relationships of HCV NS3 protease inhibitors evaluated on the drug-resistant variants A156T and D168V

    Part of Antiviral Therapy, p. 841-852, 2010.

  • de Kloe, Gerdien E; Retra, Kim; Geitmann, Matthis; Källblad, Per et al.

    Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

    Part of Journal of Medicinal Chemistry, p. 7192-7201, 2010.

  • Wang, Xiaolu; Hu, Bin; Zieba, Agata; Neumann, Nicole G et al.

    A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1

    Part of Journal of Neuroscience, p. 12584-12596, 2009.

  • Christopeit, Tony; Gossas, Thomas; Danielson, Helena

    Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor

    Part of Analytical Biochemistry, p. 39-44, 2009.

  • Danielson, U Helena

    Fragment library screening and lead characterization using SPR biosensors

    Part of Current Topics in Medicinal Chemistry, p. 1725-1735, 2009.

  • Dahl, Göran; Gutiérrez Arenas, Omar; Danielson, Helena

    Hepatitis C Virus NS3 Protease Is Activated by Low Concentrations of  Protease Inhibitors

    Part of Biochemistry, p. 11592-11602, 2009.

  • Bertucci, Carlo; Pistolozzi, Marco; Felix, Guy; Danielson, Helena

    HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study

    Part of Journal of Separation Science, p. 1625-1631, 2009.

  • Danielson, U Helena

    Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

    Part of Future Medicinal Chemistry, p. 1399-1414, 2009.

  • Elinder, Malin; Nordström, Helena; Geitmann, Matthis; Hämäläinen, Markku et al.

    Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

    Part of Journal of Biomolecular Screening, p. 395-403, 2009.

  • Simister, Philip; Schmitt, Melanie; Geitmann, Matthis; Wicht, Oliver et al.

    Structural and Functional Analysis of Hepatitis C Virus Strain JFH1 Polymerase

    Part of Journal of Virology, p. 11926-11939, 2009.

  • Rönn, Robert; Lampa, Anna; Peterson, Shane D.; Gossas, Thomas et al.

    Hepatitis C Virus NS3 Protease Inhibitors Comprising a Novel Aromatic P1 Moiety

    Part of Bioorganic & Medicinal Chemistry, p. 2955-2967, 2008.

  • Nordström, Helena; Gossas, Thomas; Hämäläinen, Markku; Källblad, Per et al.

    Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

    Part of Journal of Medicinal Chemistry, p. 3449-3459, 2008.

  • Elinder, Malin; Danielson, U Helena; Unge, Torsten; van Ham, Guido et al.

    MIV-170, a novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)

    Part of Antiviral Research, p. A37-A37, 2008.

  • Elinder, Malin; Danielson, Helena; Unge, Torsten; VanHam, Guido et al.

    MIV-170: A novel NNRTI exhibiting tight binding to HIV-1 reverse transcriptase (RT)

    2008.

  • Nurbo, Johanna; Peterson, Shane D.; Dahl, Göran; Danielson, U. Helena et al.

    β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors

    Part of Bioorganic & Medicinal Chemistry, p. 5590-5605, 2008.

  • Geitmann, Matthis; Danielson, U. Helena

    Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

    Part of Bioorganic & Medicinal Chemistry, p. 7344-7354, 2007.

  • Norgren, Anna S.; Geitmann, Matthis; Danielson, U. Helena; Arvidsson, Per I.

    Biomolecular Recognition of Glycosylated β3-Peptides by GalNAc Specific Lectins

    Part of Journal of Molecular Recognition, p. 132-138, 2007.

  • Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

    Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3

    Part of The FEBS Journal, p. 5979-5986, 2007.

  • Rönn, Robert; Gossas, Thomas; Sabnis, Yogesh A; Daoud, H et al.

    Evaluation of a diverse set of potential P-1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

    Part of Bioorganic & Medicinal Chemistry, p. 1448-1474, 2007.

  • Rönn, Robert; Gossas, Thomas; Sabnis, Yogesh A.; Daoud, Hanna et al.

    Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

    Part of Bioorganic & Medicinal Chemistry, p. 4057-4068, 2007.

  • Nurbo, Johanna; Dahl, Göran; Danielson, U Helena; Sandström, Anja

    Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

    Part of Biopolymers, p. 580-580, 2007.

  • Nurbo, Johanna; Dahl, G; Danielson, U Helena; Sandström, Anja

    Investigation of beta-amino acids as building blocks in hepatitis c virus NS3 protease inhibitors

    2007.

  • Poliakov, Anton; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

    Mechanistic studies of electrophilic protease inhibitors of full length hepatic C virus (HCV) NS3

    Part of Journal of enzyme inhibition and medicinal chemistry (Print), p. 191-199, 2007.

  • Örtqvist, Pernilla; Peterson, Shane D.; Åkerblom, Eva; Gossas, Thomas et al.

    Phenylglycine as a Novel P2 Scaffold in Hepatitis C Virus NS3 Protease Inhibitors

    Part of Bioorganic & Medicinal Chemistry, p. 1448-1474, 2007.

  • Dahl, Göran; Sandström, Anja; Åkerblom, Eva; Danielson, U. Helena

    Resistance profiling of hepatitis C virus protease inhibitors using full-length NS3

    Part of Antiviral Therapy, p. 733-740, 2007.

  • Geitmann, Matthis; Unge, Torsten; Danielson, U. Helena

    Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors

    Part of Journal of Medicinal Chemistry, p. 2367-74, 2006.

  • Backman, Dan; Monod, Michel; Danielson, U. Helena

    Biosensor-based screening and characterization of HIV-1 inhibitor interactions with Sap1, Sap2 and Sap3 from Candida albicans

    Part of Journal of Biomolecular Screening, p. 165-175, 2006.

  • Gossas, Thomas; Danielson, Helena

    Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation

    Part of Biochemical Journal, p. 393-398, 2006.

  • Gutierrez Arenas, Omar; Danielson, U. Helena

    Detection of competitive enzyme inhibition with end point progress curve data

    Part of Analytical Biochemistry, p. 11-19, 2006.

  • Rönn, Robert; Sabnis, Yogesh A; Gossas, Thomas; Åkerblom, Eva et al.

    Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3

    Part of Bioorganic & Medicinal Chemistry, p. 544-559, 2006.

  • Sookkongwaree, K; Geitmann, Matthis; Roengsumran, S; Petsom, A et al.

    Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora

    Part of Pharmazie, p. 717-721, 2006.

  • Geitmann, Matthis; Unge, Torsten; Danielson, U. Helena

    Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance

    Part of Journal of Medicinal Chemistry, p. 2375-87, 2006.

  • Gutierrez Arenas, Omar; Danielson, U Helena

    Sensitivity analysis and error structure of progress curves

    Part of Analytical Biochemistry, p. 1-10, 2006.

  • Cimitan, Samanta; Lindgren, Maria T.; Bertucci, Carlo; Danielson, U. Helena

    Early absorption and distribution analysis of antitumor and anti-AIDS drugs: lipid membrane and plasma protein interactions

    Part of Journal of Medicinal Chemistry, p. 3536-46, 2005.

  • Rönn, Robert; Gossas, T; Sabnis, Y A; Åkerblom, E et al.

    Novel C-terminal functionalities in hepatitis C virus NS3 protease inhibitors

    2005.

  • Poliakov, Anton; Danielson, U. Helena

    Refolding of the full-length non-structural protein 3 of hepatitis C virus

    Part of Protein Expression and Purification, p. 298-305, 2005.

  • Shuman, Cynthia; Vrang, Lotta; Danielson, U. Helena

    Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

    Part of Journal of Medicinal Chemistry, p. 5953-61, 2004.

  • Shuman, Cynthia F.; Hämäläinen, Markku; Danielson, U. Helena

    Kinetic and thermodynamic characterization of HIV-1 protease inhibitors

    Part of Journal of Molecular Recognition, p. 106-19, 2004.

  • Poliakov, Anton; Johansson, Anja; Åkerblom, Eva; Lindeberg, Gunnar et al.

    Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

    Part of Antiviral Research, p. A51-A51, 2004.

  • Poliakov, Anton; Johansson, A; Åkerblom, E; Lindeberg, G et al.

    Optimisation of peptide-based inhibitors of full-length hepatitis C virus NS3 protease

    2004.

  • Poliakov, Anton; Johansson, Anja; Åkerblom, Eva; Oscarsson, Karin et al.

    Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

    Part of Biochimica et Biophysica Acta, p. 51-59, 2004.

  • Geitmann, Matthis; Danielson, U. Helena

    Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology

    Part of Analytical Biochemistry, p. 203-214, 2004.

  • Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Wiklund, Karin et al.

    Acyl sulfonamides as potent protease inhibitors of the hepatitis C virus full-length NS3 (protease-helicase/NTPase): a comparative study of different C-terminals

    Part of Bioorganic & Medicinal Chemistry, p. 2551-2568, 2003.

  • Gossas, Thomas; Danielson, U. Helena

    Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors

    Part of Journal of Molecular Recognition, p. 203-212, 2003.

  • Beyer, B; Rubin, J; Johnson, J; Chung, A et al.

    Candida albicans secreted aspartic peptidase specificity: A chromogenic combinatorial approach

    Part of Biopolymers, p. 310-P025, 2003.

  • Shuman, Cynthia F.; Markgren, Per-Olof; Hämäläinen, Markku; Danielson, U. Helena

    Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

    Part of Antiviral Research, p. 235-242, 2003.

  • Backman, Dan; Danielson, U. Helena

    Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans

    Part of Biochimica et Biophysica Acta - Proteins and Proteomics, p. 184-195, 2003.

  • Andersson, Hans O.; Fridborg, Kerstin; Löwgren, Seved; Alterman, Mathias et al.

    Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors

    Part of European Journal of Biochemistry, p. 1746-1758, 2003.

  • Oscarsson, Karin; Poliakov, Anton; Oscarson, Stefan; Danielson, U. Helena et al.

    Peptide-based inhibitors of hepatitis C virus full-length NS3 (protease-helicase/NTPase): model compounds towards small molecule inhibitors

    Part of Bioorganic & Medicinal Chemistry, p. 2955-2963, 2003.

  • Li, Ming; Poliakov, Anton; Danielson, U. Helena; Su, Zhiguo et al.

    Refolding of a recombinant full-length non-structural (NS3) protein from hepatitis C virus by chromatographic procedures

    Part of Biotechnology letters, p. 1729-1734, 2003.

  • Poliakov, Anton; Hubatsch, Ina; Shuman, Cynthia F; Stenberg, Gun et al.

    Expression and purification of recombinant full-length NS3 protease-helicase from a new variant of Hepatitis C virus

    Part of Protein Expression and Purification, p. 363-371, 2002.

  • Blumenzweig, I; Baraz, L; Friedler, A; Danielson, U. Helena et al.

    HIV-1 Vif-derived peptide inhibits drug-resistant HIV proteases

    Part of Biochemical and Biophysical Research Communications - BBRC, p. 832-840, 2002.

  • Johansson, Anja; Åkerblom, Eva; Poliakov, Anton; Lindeberg, Gunnar et al.

    Peptide-based protease inhibitors of the hepatitis C virus full-length NS3 protein (protease-helicase/NTPase)

    Part of Journal of Peptide Science, p. S165-S165, 2002.

  • Markgren, Per-Olof; Schaal, Wesley; Hämäläinen, Markku; Karlén, Anders et al.

    Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

    Part of Journal of Medicinal Chemistry, p. 5430-5439, 2002.

  • Ahlsén, Göran; Hultén, Johan; Shuman, Cynthia; Poliakov, Anton et al.

    Resistance profiles of cyclic and linear inhibitors of HIV-1 protease

    Part of Antiviral Chemistry & Chemotherapy, p. 27-37, 2002.

  • Johansson, Anja; Poliakov, Anton; Åkerblom, Eva; Lindeberg, Gunnar et al.

    Tetrapeptides as potent protease inhibitors of Hepatitis C Virus full-length NS3 (protease-helicase/NTPase)

    Part of Bioorganic & Medicinal Chemistry, p. 3915-22, 2002.

  • Sönksen, C. P.; Roepstorff, P.; Markgren, Per-Olof; Danielson, U. Helena et al.

    Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry

    Part of European journal of mass spectrometry, p. 385-391, 2001.

  • Markgren, Per-Olof; Lindgren, Maria T.; Gertow, Karl; Karlsson, Robert et al.

    Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology

    Part of Analytical Biochemistry, p. 207-218, 2001.

  • Johansson, Anja; Hubatsch, Ina; Åkerblom, Eva; Lindeberg, Gunnar et al.

    Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain

    Part of Bioorganic & Medicinal Chemistry Letters, p. 203-206, 2001.

  • Alterman, Mathias; Sjöbom, Hans; Säfsten, Pär; Markgren, Per-Olof et al.

    P1/P1' modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

    Part of European Journal of Pharmaceutical Sciences, p. 203-212, 2001.

  • Schaal, Wesley; Karlsson, Anna; Ahlsén, Göran; Lindberg, Jimmy et al.

    Synthesis and comperative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors

    Part of Journal of Medicinal Chemistry, p. 155-169, 2001.

  • Hämäläinen, Markku D.; Markgren, Per-Olof; Schaal, Wesley; Karlén, Anders et al.

    Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen

    Part of Journal of Biomolecular Screening, p. 353-359, 2000.

  • Markgren, Per-Olof; Hämäläinen, Markku; Danielson, U. Helena

    Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology

    Part of Analytical Biochemistry, p. 71-78, 2000.

  • Alterman, Mathias; Andersson, Hans O.; Garg, Neeraj; Ahlsén, Göran et al.

    Design and fast synthesis of C-terminal duplicated potent C2-symmetric P1/P1'-modified HIV-1 protease inhibitors

    Part of Journal of Medicinal Chemistry, p. 3835-3844, 1999.

  • Hultén, Johan; Andersson, Hans O.; Schaal, Wesley; Danielson, U. Helena et al.

    Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains

    Part of Journal of Medicinal Chemistry, p. 4054-4061, 1999.

  • Danielson, U. Helena; Jiang, Fanyi Y; Hansson, Lars O.; Mannervik, Bengt

    Probing the kinetic mechanism and coenzyme specificity of glutathione reductase from the cyanobacterium Anabaena PCC 7120 by redesign of the pyridine-nucleotide-binding site

    Part of Biochemistry, p. 9254-9263, 1999.

  • Hultén, Johan; Schaal, Wesley; Unge, Torsten; Danielson, U Helena et al.

    Cyclic 7-membered sulfamide HIV-1 protease inhibitors

    Part of Antiviral Research, p. A57-A57, 1998.

  • Bäckbro, Kristina; Andersson, Hans; Bonham, Nick M; Classon, Björn et al.

    Cyclic urea and sulfamide-based inhibitors of HIV-1 protease: Changes in binding mode upon modifications in the P1/P1 side chain

    Part of Antiviral Research, p. A56-A56, 1998.

  • Alterman, Mathias; Björsne, Magnus; Mühlman, Anna; Classon, Björn et al.

    Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors: Use of L-mannaric acid as a peptidomimetic scaffold

    Part of Journal of Medicinal Chemistry, p. 3782-3792, 1998.

  • Noreen, Ylva; Ringbom, Therese; Perera, Premila; Danielson, Helena et al.

    Development of a radiochemical cyclooxygenase-1 and 2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis

    Part of Journal of natural products (Print), p. 2-7, 1998.

  • Zuccarello, Guido; Bouzide, Abderrahim; Kvarnstrom, Ingemar; Niklasson, Gunilla et al.

    HIV-1 protease inhibitors based on acyclic carbohydrates

    Part of Journal of Organic Chemistry, p. 4898-4906, 1998.

  • Danielson, Helena; Lindgren, Maria T.; Markgren, Per-Olof; Nillroth, Ulrika

    Investigation of an allosteric site of HIV-1 proteinase involved in inhibition by Cu2+

    Part of Advances in Experimental Medicine and Biology, p. 99-103, 1998.

  • Markgren, Per-Olof; Hämäläinen, Markku; Danielson, U. Helena

    Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology

    Part of Analytical Biochemistry, p. 340-350, 1998.

  • Brånalt, J; Kvarnstrom, I; Classon, B; Samuelsson, B et al.

    A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'-phenylethyl]oxirane: a useful building block in the synthesis of HIV protease inhibitors

    Part of Tetrahedron Letters, p. 3483-3486, 1997.

  • Hultén, Johan; Bonham, Nicholas M; Nillroth, Ulrika; Hansson, Tomas et al.

    Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities

    Part of Journal of Medicinal Chemistry, p. 885-897, 1997.

  • Nillroth, Ulrika; Vrang, Lotta; Markgren, Per-Olof; Hultén, Johan et al.

    Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs

    Part of Antimicrobial Agents and Chemotherapy, p. 2383-2388, 1997.

  • Nöteberg, Daniel; Brånalt, Jonas; Kvarnström, Ingemar; Classon, Björn et al.

    Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

    Part of Tetrahedron, p. 7975-7984, 1997.

  • Niklasson, Gunilla; Kvarnström, Ingemar; Classon, Björn; Samuelsson, Bertil et al.

    Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol

    Part of Journal of carbohydrate chemistry, p. 555-569, 1996.

  • Kolm, Rüdiger H.; Danielson, U Helena; Zhang, Y.uesheng; Talalay, Paul et al.

    Isothiocyanates as substrates for human glutathione transferases: structure-activity studies

    Part of Biochemical Journal, p. 453-459, 1995.

  • Nillroth, Ulrika; Besidsky, Yosef; Classon, Björn; Chattopahyaya, Jyoti et al.

    Specific interaction between HIV-1 proteinase and 5'-phosphate peptidomimetic derivatives of nucleoside analogues

    Part of Drug design and discovery, p. 43-54, 1995.

  • Nillroth, Ulrika; Vrang, Lotta; Ahlsén, Göran; Besidsky, Y et al.

    The use of 5'-phosphate derivatives of nucleoside analogs as inhibitors of HIV-1 replication

    Part of Antiviral Chemistry & Chemotherapy, p. 50-64, 1995.

  • Chaga, Grigoriy; Widersten, Mikael; Andersson, Lennart; Porath, Jerker et al.

    Engineering of a metal coordinating site into human glutathione transferase M1-1 based on immobilized metal ion affinity chromatography of homologous rat enzymes

    Part of Protein Engineering, p. 1115-1119, 1994.

  • Goobar, Laura; Danielson, U Helena; Brodin, Peter; Grundström, Thomas et al.

    High-yield purification of HIV-1 proteinase expressed by a synthetic gene in Escherichia coli

    Part of Protein Expression and Purification, p. 15-23, 1991.

  • Neuzil, Jiri; Danielson, Helena; Welch, G Rickey; Ovádi, Judit

    Cooperative effect of fructose bisphosphate and glyceraldehyde-3-phosphate dehydrogenase on aldolase action

    Part of Biochimica et Biophysica Acta, p. 307-312, 1990.

  • Wallin, Margareta; Deinum, Johanna; Goobar, Laura; Danielson, U Helena

    Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases

    Part of Journal of General Virology, p. 1985-1991, 1990.

  • Mannervik, Bengt; Danielson, U Helena

    Glutathione transferases - structure and catalytic activity

    Part of Crc Critical Reviews in Biochemistry, p. 283-337, 1988.

  • Danielson, U Helena; Mannervik, Bengt

    Paradoxical inhibition of rat glutathione transferase 4-4 by indomethacin explained by substrate-inhibitor-enzyme complexes in a random-order sequential mechanism

    Part of Biochemical Journal, p. 705-711, 1988.

  • Principato, Giovanni B; Danielson, U Helena; Mannervik, Bengt

    Relaxed thiol substrate specificity of glutathione transferase effected by a non-substrate glutathione derivative

    Part of FEBS Letters, p. 155-158, 1988.

  • Mannervik, Bengt; Castro, Victor M; Danielson, U Helena; Platz, A et al.

    Expression of class-pi glutathione transferase in drug-resistant human-melanoma cells

    Part of Proceedings of the American Association of Cancer Research, p. 5-5, 1987.

  • Danielson, U Helena; Esterbauer, Hermann; Mannervik, Bengt

    Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

    Part of Biochemical Journal, p. 707-713, 1987.

  • Ålin, Per; Danielson, U. Helena; Mannervik, Bengt

    4-Hydroxyalk-2-enals are substrates for glutathione transferase

    Part of FEBS Letters, p. 267-270, 1985.

  • Danielson, U Helena; Mannervik, Bengt

    Kinetic independence of the subunits of cytosolic glutathione transferase from the rat

    Part of Biochemical Journal, p. 263-267, 1985.

  • Ålin, Per; Jensson, Helgi; Guthenberg, Claes; Danielson, U Helena et al.

    Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

    Part of Analytical Biochemistry, p. 313-320, 1985.

  • Mannervik, Bengt; Ålin, P; Danielson, U Helena; Guthenberg, C et al.

    STRUCTURAL DATA AND ENZYMATIC-PROPERTIES DEFINING 3 CLASSES OF MAMMALIAN CYTOSOLIC GLUTATHIONE TRANSFERASE

    Part of Federation proceedings, p. 471-471, 1985.

  • Lindgren, Maria T.; Markgren, Per-Olof; Nillroth, Ulrika; Danielson, U. Helena

    Inhibition of HIV-1 protease by Cu2+ occurs by a reversible allosteric mechanism involving His-69

  • Gossas, Thomas; Nordström, Helena; Wallberg, Hans; Danielson, Helena

    The high affinity of hydroxamate-based MMP-12 inhibitors is due to an inherently slow dissociation rate of the enzyme-inhibitor complex

  • Geitmann, Matthis; Danielson, U. Helena

    Thermodynamic analysis of non-nucleoside inhibitor binding to HIV-1 reverse transcriptase